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Transglutaminase inhibitors

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Transglutaminases are involved in a multitude of physiological processes. One way to explore these processes is to use specific inhibitors. In addition to naturally occurring inhibitors such as the protein tridegin, rationally designed synthetic, small molecule inhibitors such as Z-DON (Z006) will be of immeasurable help to scientists wishing to decipher the enigmatic roles of individual transglutaminases.

„DON“ compounds
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2-[(2-oxopropyl)thio] imidazolium derivates
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Michael acceptor peptidomimetics
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Lysine analogues- chloromethyl ketones
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